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KMID : 0361420050290020201
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Journal of Korean Academy of Rehabilitation Medicine
2005 Volume.29 No. 2 p.201 ~ p.208
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The Significance of Evoked Potentials according to the Injury Severity of Spinal Cord Contusive Rat Model
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Lee So-Young
Kim Ji-Hoon
Cheon Seung-Wook
Kim Jae-Hyung
Choi In-Sung
Lee Sam-Gyu
Jeon Pyeung-Sik
Kim Hyung-Beom
Park Seung-Jin
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Abstract
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Objective: To investigate the prognostic values of somatosensory evoked potential (SEP) and electric motor evoked potential (eMEP) studies according to the varying spinal cord injury by incremental height of weight-drop impactor and progress of functional recovery
Methods: Thirty Sprague-Dawley rats (300+/-50 grams, male) were used. The spinal cord injury was made by weight-drop device from 12.5, 25.0 and 50.0 mm height at T10 cord segment. The three groups of each drop-height (n=10) and laminectomized sham group (n=10) were subjected to functional analysis using inclined plane test and Basso Beattie Bresnahan (BBB) locomotor scales at the 1, 3, 5, 7, 14, 21 and 28th day after the contusive injury. SEP by sciatic nerve stimulation and eMEP at the gastrocnemius muscle were recorded.
Results: Maximal angle of inclination and BBB scales had an inverse relation with the contusion severity (p <0.05). There were significant correlations among the changes of peak latencies and amplitudes of SEP, contusion severity, and the motor recovery (p <0.05). The changes of onset latencies and amplitudes of eMEP were significantly correlated with the contusion severity and the motor recovery (p <0.05).
Conclusion: The SEP and eMEP studies had significant values according to the contusion severity and functional recovery in contusive rat model of the spinal cord.
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KEYWORD
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Spinal Cord Contusion, Somatosensory evoked potential, Electric motor evoked potenital, Functional recovery, Spinal Cord Contusive Rat Model
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